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The antibody against KALRN was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Duo. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against KALRN was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Duo. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
| Cat.No | ADC-33405A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KALRN |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Duo. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60229 |
Uniprot Id
O60229
Target Species
Human
Target Name
KALRN
Target Full Name
Kalirin
Target Function
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Target Involvement
Coronary heart disease 5 (CHDS5)
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.
Target Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Target Tissue Specificity
Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
Target Synonyms
Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin (isoform 2); Kalirin; KALRN; KALRN_HUMAN; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD
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