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The antibody against KBTBD7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 475-684 of human KBTBD7 (NP_115514.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against KBTBD7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 475-684 of human KBTBD7 (NP_115514.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02533A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KBTBD7 |
| Target Synonyms | KBTBD7 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat brain, 293T, A-549, HL-60, MCF7, Mouse brain, Rat kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 475-684 of human KBTBD7 (NP_115514.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WVZ9 | Immunogen Sequence |
Uniprot Id
Q8WVZ9
Target Species
Human
Target Name
KBTBD7
Target Full Name
Kelch repeat and BTB domain-containing protein 7
Target Function
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Synonyms
1110008P08Rik; AU045792; DKFZP434E2318; Gm295; KBTB7_HUMAN; KBTBD 7; KBTBD7; Kelch repeat and BTB (POZ) domain containing 7; Kelch repeat and BTB domain containing protein 7; Kelch repeat and BTB domain-containing protein 7; OTTHUMP00000018313
Target Background
The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1.
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