Rabbit anti-Human KCNH6 Polyclonal Antibody

Uniprot Id

Q9H252

Target Species

Human

Target Name

KCNH6

Target Full Name

Voltage-gated inwardly rectifying potassium channel KCNH6

Target Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.2/KCNH6 sub-subfamily

Target Tissue Specificity

Expressed in prolactin-secreting adenomas.

Target Synonyms

KCNH6; ERG2; Potassium voltage-gated channel subfamily H member 6; Ether-a-go-go-related gene potassium channel 2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2; Voltage-gated potassium channel subunit Kv11.2

Target Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms.