Rabbit anti-Human KCNJ16 Polyclonal Antibody

Uniprot Id

Q9NPI9

Target Species

Human

Target Name

KCNJ16

Target Full Name

Inward rectifier potassium channel 16

Target Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.

Target Subcellular Location

Membrane; Multi-pass membrane protein. Basolateral cell membrane.

Target Protein Families

Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ16 subfamily

Target Tissue Specificity

Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.

Target Synonyms

KCNJ16; Inward rectifier potassium channel 16; Inward rectifier K(+ channel Kir5.1; Potassium channel, inwardly rectifying subfamily J member 16

Target Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene.