Rabbit anti-Human KCNJ8 Polyclonal Antibody

Uniprot Id

Q15842

Target Species

Human

Target Name

KCNJ8

Target Full Name

ATP-sensitive inward rectifier potassium channel 8

Target Function

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Target Involvement

Sudden infant death syndrome (SIDS); Hypertrichotic osteochondrodysplasia (HTOCD)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ8 subfamily

Target Tissue Specificity

Predominantly detected in fetal and adult heart.

Target Synonyms

KCNJ8; ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+ channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1

Target Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS).