Rabbit anti-Human KCNQ5 Polyclonal Antibody

Uniprot Id

Q9NR82

Target Species

Human

Target Name

KCNQ5

Target Full Name

Potassium voltage-gated channel subfamily KQT member 5

Target Function

Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.

Target Involvement

Mental retardation, autosomal dominant 46 (MRD46)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.5/KCNQ5 sub-subfamily

Target Tissue Specificity

Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.

Target Synonyms

KCNQ 5; KCNQ5; KCNQ5_HUMAN; KQT like 5 ; KQT-like 5; Kv7.5; OTTHUMP00000064152; OTTHUMP00000064153; Potassium channel alpha subunit KvLQT5; Potassium channel protein; Potassium channel subunit alpha KvLQT5; Potassium voltage gated channel KQT like subfamily member 5; Potassium voltage gated channel subfamily KQT member 5; Potassium voltage-gated channel subfamily KQT member 5; Voltage gated potassium channel subunit Kv7.5; Voltage-gated potassium channel subunit Kv7.5

Target Background

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene.