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The antibody against KDM5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1400-1690 of human KDM5A (P29375) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ChIP, ELISA.
The antibody against KDM5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1400-1690 of human KDM5A (P29375) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ChIP, ELISA.
| Cat.No | ADA-13903A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KDM5A |
| Target Synonyms | RBP2; RBBP2; RBBP-2; KDM5A | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HepG2, Mouse lung | Application | ELISA, WB, ChIP, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1690 of human KDM5A (P29375). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P29375 | Immunogen Sequence |
Uniprot Id
P29375
Target Species
Human
Target Name
KDM5A
Target Full Name
Lysine-specific demethylase 5A
Target Function
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells.
Target Subcellular Location
Nucleus, nucleolus. Nucleus.
Target Protein Families
JARID1 histone demethylase family
Target Research Area
Transcription
Target Synonyms
Histone demethylase JARID1A; JARID1A; Jumonji/ARID domain containing protein 1A; Jumonji/ARID domain-containing protein 1A; Kdm5a; KDM5A_HUMAN; Lysine-specific demethylase 5A; RBBP-2; RBBP2; RBP2; Retinoblastoma binding protein 2; Retinoblastoma-binding protein 2
Target Background
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.
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