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The antibody against KEL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 70-310 of human KEL (NP_000411.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against KEL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 70-310 of human KEL (NP_000411.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01268A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KEL |
| Target Synonyms | ECE3; Kell; CD238; KEL | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A375, K-562, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 70-310 of human KEL (NP_000411.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P23276 | Immunogen Sequence |
Uniprot Id
P23276
Target Species
Human
Target Name
KEL
Target Full Name
Kell blood group glycoprotein
Target Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Target Protein Families
Peptidase M13 family
Target Tissue Specificity
Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythr
Target Synonyms
KEL; Kell blood group glycoprotein; CD antigen CD238
Target Background
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
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