Rabbit anti-Human KHDRBS2 Polyclonal Antibody

The antibody against KHDRBS2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-00401A

Number

Cat.No	ADA-00401A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	KHDRBS2
Target Synonyms	SLM1; SLM-1; KHDRBS2	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, Jurkat, K-562	Application	ELISA, WB, IHC-P

Cat.No

ADA-00401A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

KHDRBS2

Target Synonyms

SLM1; SLM-1; KHDRBS2

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, Jurkat, K-562

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2).	Target Species	Human
Immunogen Sequence	TAPSRGRGGAIPPPPPPGRGVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGYGGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQRSARGGYREHPYGRY	Uniprot ID	Q5VWX1

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2).

Target Species

Human

Immunogen Sequence

TAPSRGRGGAIPPPPPPGRGVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGYGGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQRSARGGYREHPYGRY

Uniprot ID

Q5VWX1

Background Information

Uniprot Id

Q5VWX1
Target Species

Human
Target Name

KHDRBS2
Target Full Name

KH domain-containing, RNA-binding, signal transduction-associated protein 2
Target Function

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
Target Subcellular Location

Nucleus.
Target Protein Families

KHDRBS family
Target Tissue Specificity

Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.
Target Synonyms

KH domain containing; RNA binding; signal transduction associated protein 2; 6330586C16Rik; bA535F17.1; FLJ38664; hSLM 1; hSLM-1; KH domain containing; RNA binding; signal transduction associated 2; KH domain-containing; KHDR2_HUMAN; khdrbs2; MGC26664; RNA-binding; Sam68 like mammalian protein 1; Sam68-like mammalian protein 1; signal transduction-associated protein 2; SLM 1; SLM-1; SLM1
Target Background

Predicted to enable mRNA binding activity and poly(A) binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus.

Rabbit anti-Human KHDRBS2 Polyclonal Antibody

Specifications

Immunogen Information

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