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The antibody against KIDINS220 was raised in rabbit using the Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against KIDINS220 was raised in rabbit using the Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using KIDINS220 Antibody at dilution of 1:1002
| Cat.No | ADC-11041A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KIDINS220 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULH0 |
Uniprot Id
Q9ULH0
Target Species
Human
Target Name
KIDINS220
Target Full Name
Kinase D-interacting substrate of 220 kDa
Target Function
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Target Involvement
Spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Late endosome. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Target Tissue Specificity
Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
Target Synonyms
Ankyrin repeat-rich membrane-spanning protein; arms; KDIS_HUMAN; kidins220; Kinase D interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; rgd 619949
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