Rabbit anti-Human KIF22 Polyclonal Antibody

Uniprot Id

Q14807

Target Species

Human

Target Name

KIF22

Target Full Name

Kinesin-like protein KIF22

Target Function

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.

Target Involvement

Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2)

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family

Target Tissue Specificity

Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.

Target Synonyms

A 328A3.2; KID; KIF 22; kif22; KIF22_HUMAN; Kinesin family member 22; Kinesin like 4; Kinesin like DNA binding protein; Kinesin like DNA binding protein pseudogene; Kinesin like protein 4; Kinesin like protein KIF22; Kinesin-like DNA-binding protein; Kinesin-like protein 4; Kinesin-like protein KIF22; KNSL 4; KNSL4; OBP 1; OBP 2; OBP; OBP1; OBP2; Origin of plasmid DNA replication binding protein; OriP binding protein; OTTHUMP00000123406; SEMDJL2

Target Background

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.