Rabbit anti-Human KIR3DL3 Polyclonal Antibody

Uniprot Id

Q8N743

Target Species

Human

Target Name

KIR3DL3

Target Full Name

Killer cell immunoglobulin-like receptor 3DL3

Target Function

Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily

Target Synonyms

CD158 antigen-like family member Z; CD158z; KI3L3_HUMAN; Killer cell immunoglobulin-like receptor 3DL3; Killer cell inhibitory receptor 1; KIR3DL3

Target Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.