Rabbit anti-Human KIRREL Polyclonal Antibody

The antibody against KIRREL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 17-200 of human KIRREL (NP_060710.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00664A

Number

Cat.No	ADA-00664A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	KIRREL
Target Synonyms	NEPH1; KIRREL; NPHS23	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, Mouse lung	Application	ELISA, WB

Cat.No

ADA-00664A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

KIRREL

Target Synonyms

NEPH1; KIRREL; NPHS23

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, Mouse lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 17-200 of human KIRREL (NP_060710.3).	Target Species	Human
Immunogen Sequence	QGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC	Uniprot ID	Q96J84

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 17-200 of human KIRREL (NP_060710.3).

Target Species

Human

Immunogen Sequence

QGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC

Uniprot ID

Q96J84

Background Information

Uniprot Id

Q96J84
Target Species

Human
Target Name

KIRREL1
Target Full Name

Kin of IRRE-like protein 1
Target Function

Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm.
Target Protein Families

Immunoglobulin superfamily
Target Tissue Specificity

Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Target Synonyms

FLJ10845; Kin of IRRE like (Drosophila); Kin of IRRE like; Kin of IRRE like protein 1; Kin of IRRE-like protein 1; Kin of irregular chiasm like protein 1; Kin of irregular chiasm-like protein 1; KIRR1_HUMAN; Kirrel; MGC129542; MGC129543; NEPH 1; NEPH1; Nephrin like protein 1; Nephrin related; Nephrin-like protein 1; OTTHUMP00000024055
Target Background

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).

Rabbit anti-Human KIRREL Polyclonal Antibody

Specifications

Immunogen Information

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