Rabbit anti-Human KLHL12 Polyclonal Antibody

Uniprot Id

Q53G59

Target Species

Human

Target Name

KLHL12

Target Full Name

Kelch-like protein 12

Target Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.

Target Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle.

Target Tissue Specificity

Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

C3IP1; CUL3 interacting protein 1; CUL3-interacting protein 1; DKIR ; DKIR homolog; FLJ27152; hDKIR; Kelch like 12 (Drosophila); Kelch like 12; Kelch like 12 variant; Kelch like protein 12; Kelch like protein C3IP1; kelch-like family member 12; Kelch-like protein 12; KLH12_HUMAN; KLHL 12; klhl12; OTTHUMP00000038799