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The antibody against KLHL13 was raised in rabbit using the Recombinant Human Kelch-like protein 13 protein (1-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against KLHL13 was raised in rabbit using the Recombinant Human Kelch-like protein 13 protein (1-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using KLHL13 Antibody at dilution of 1:1002
| Cat.No | ADC-16550A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLHL13 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kelch-like protein 13 protein (1-260AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9P2N7 |
Uniprot Id
Q9P2N7
Target Species
Human
Target Name
KLHL13
Target Full Name
Kelch-like protein 13
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
Target Synonyms
BKLHD2; BTB and kelch domain containing 2; BTB and kelch domain containing 2 KIAA1309; BTB and kelch domain containing protein 2; BTB and kelch domain-containing protein 2; FLJ10262; Kelch like 13 (Drosophila); Kelch like protein 13; Kelch-like protein 13; KIAA1309; KLH13_HUMAN; KLHL13; MGC74791
Target Background
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.
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