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The antibody against KLK10 was raised in rabbit using the Recombinant Human Kallikrein-10 protein (35-276AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against KLK10 was raised in rabbit using the Recombinant Human Kallikrein-10 protein (35-276AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using KLK10 Antibody at dilution of 1:1002
| Cat.No | ADC-17495A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLK10 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kallikrein-10 protein (35-276AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43240 |
Uniprot Id
O43240
Target Species
Human
Target Name
KLK10
Target Full Name
Kallikrein-10
Target Function
Has a tumor-suppressor role for NES1 in breast and prostate cancer.
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase S1 family, Kallikrein subfamily
Target Tissue Specificity
Expressed in breast, ovary and prostate.
Target Research Area
Cell Cycle
Target Synonyms
Breast normal epithelial cell associated serine protease; Kallikrein related peptidase 10; Kallikrein-10; Kallikrein10; KLK 10; KLK10; KLK10_HUMAN; NES 1; NES1; Normal epithelial cell specific 1; Normal epithelial cell-specific 1; Protease serine like 1; Protease serine-like 1; PRSS L1; PRSSL 1; PRSSL1
Target Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
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