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The antibody against KLK4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 30-254 of human KLK4 (NP_004908.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against KLK4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 30-254 of human KLK4 (NP_004908.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02914A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLK4 |
| Target Synonyms | ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein; KLK4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse brain, Rat testis | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 30-254 of human KLK4 (NP_004908.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y5K2 | Immunogen Sequence |
Uniprot Id
Q9Y5K2
Target Species
Human
Target Name
KLK4
Target Full Name
Kallikrein-4
Target Function
Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix.
Target Involvement
Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1)
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase S1 family, Kallikrein subfamily
Target Tissue Specificity
Expressed in prostate.
Target Synonyms
ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein; KLK4
Target Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene.
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