Name: Rabbit anti-Human KMT5A Polyclonal Antibody
SKU: ADC-14909A
Availability: InStock

Rabbit anti-Human KMT5A Polyclonal Antibody

The antibody against KMT5A was raised in rabbit using the Recombinant Human N-lysine methyltransferase KMT5A protein (136-258AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.

ADC-14909A

$299.00

Number

Cat.No

ADC-14909A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

KMT5A

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Application

ELISA, IHC

Storage

Upon receipt

Immunogen Description

Recombinant Human N-lysine methyltransferase KMT5A protein (136-258AA)

Target Species

Human

Immunogen Sequence

Complete sequences for the immunogen, target protein, and peptides are available upon request.

Uniprot ID

Q9NQR1

Background Information

Uniprot Id

Q9NQR1
Target Species

Human
Target Name

KMT5A
Target Full Name

N-lysine methyltransferase KMT5A
Target Function

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
Target Subcellular Location

Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Target Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, PR/SET subfamily
Target Synonyms

H4 K20 HMTase; H4 K20 specific histone methyltransferase; H4-K20-HMTase SETD8; Histone H4 K20 methyltransferase; Histone lysine N methyltransferase H4 lysine 20 specific; Histone-lysine N-methyltransferase SETD8; Lysine N-methyltransferase 5A; N-lysine methyltransferase SETD8; Pr SET 7; Pr SET7; PR-Set7; PR/SET domain containing protein 07; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; PrSET7; SET 07; SET 8; SET domain containing (lysine methyltransferase) 8; SET domain containing 8; SET domain containing lysine methyltransferase 8; SET domain containing protein 8; SET domain-containing protein 8; SET07; SET8; SETD 8; setd8; SETD8_HUMAN
Target Background

The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation.

Rabbit anti-Human KMT5A Polyclonal Antibody

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Immunogen Information

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