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The antibody against KPTN was raised in rabbit using the Human KPTN as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against KPTN was raised in rabbit using the Human KPTN as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-52915A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KPTN |
| Target Synonyms | 2E4 antibody; actin associated protein 2E4 antibody; actin binding protein antibody; Actin-associated protein 2E4 antibody; Kaptin antibody; Kptn antibody; KPTN protein antibody; KPTN_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human KPTN | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y664 |
Uniprot Id
Q9Y664
Target Species
Human
Target Name
KPTN
Target Full Name
KICSTOR complex protein kaptin
Target Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Target Involvement
Mental retardation, autosomal recessive 41 (MRT41)
Target Subcellular Location
Lysosome membrane. Cell projection, lamellipodium. Cell projection, stereocilium.
Target Synonyms
2E4; actin associated protein 2E4; actin binding protein; Actin-associated protein 2E4; Kaptin; Kptn; KPTN protein; KPTN_HUMAN
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