Name: Mouse anti-Human KRT14 Monoclonal antibody
SKU: ADC-56005A
Availability: InStock

Mouse anti-Human KRT14 Monoclonal antibody

The antibody against KRT14 was raised in mouse using the Synthesized peptide derived from human Cytokeratin 14 as the immunogen. This antibody exists as a non-conjugated isotype IgG1, Kappa. The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody has been validated on ELISA, IHC.

ADC-56005A

$299.00

Number

Cat.No

ADC-56005A

Clonality

Monoclonal

Host Species

Mouse

Target Name

KRT14

Target Synonyms

Dowling-Meara, Koebner) antibody; Keratin 14 antibody; Keratin antibody; Keratin type I cytoskeletal 14 antibody; Keratin, type I cytoskeletal 14 antibody; Keratin-14 antibody; Keratin14 antibody; Koebner antibody; Krt 14 antibody; Krt14 antibody; NFJ antibody; OTTHUMP00000164624 antibody; type I cytoskeletal 14 antibody

Form

Liquid

Species Reactivity

Human

Isotype

IgG1, Kappa

Storage Buffer

0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol

Purification Method

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugate

Non-conjugated

Application

ELISA, IHC

Storage

Upon receipt

Immunogen Description

Synthesized peptide derived from human Cytokeratin 14

Target Species

Human

Immunogen Sequence

Complete sequences for the immunogen, target protein, and peptides are available upon request.

Uniprot ID

P02533

Background Information

Uniprot Id

P02533
Target Species

Human
Target Name

KRT14
Target Full Name

Keratin, type I cytoskeletal 14
Target Function

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Target Involvement

Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS); Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS); Epidermolysis bullosa simplex, Koebner type (K-EBS); Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1); Naegeli-Franceschetti-Jadassohn syndrome (NFJS); Dermatopathia pigmentosa reticularis (DPR)
Target Subcellular Location

Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern.
Target Protein Families

Intermediate filament family
Target Tissue Specificity

Expressed in the corneal epithelium (at protein level). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the
Target Research Area

Signal Transduction
Target Synonyms

CK 14; CK-14; ck14; Cytokeratin 14; Cytokeratin-14; Cytokeratin14; Dowling Meara; EBS3; EBS4; Epidermolysis bullosa simplex; K14; K1C14_HUMAN; Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); Keratin 14; Keratin; Keratin type I cytoskeletal 14; Keratin, type I cytoskeletal 14; Keratin-14; Keratin14; Koebner; Krt 14; Krt14; NFJ; OTTHUMP00000164624; type I cytoskeletal 14
Target Background

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.

Mouse anti-Human KRT14 Monoclonal antibody

Specifications

Immunogen Information

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