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The antibody against KRT6B was raised in rabbit using the Synthetic peptide corresponding to a region derived from internal residues of Human keratin 6B as the immunogen. This antibody exists as a polyclonal antibody to the immunogen, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against KRT6B was raised in rabbit using the Synthetic peptide corresponding to a region derived from internal residues of Human keratin 6B as the immunogen. This antibody exists as a polyclonal antibody to the immunogen, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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| Cat.No | ADC-40632A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KRT6B |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | 0.05% NaN3, 50% Glycerol, Rabbit IgG in pH7.3 PBS | Purification Method | Antigen affinity purified |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide corresponding to a region derived from internal residues of Human keratin 6B | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P04259 |
Uniprot Id
P04259
Target Species
Human
Target Name
KRT6B
Target Full Name
Keratin, type II cytoskeletal 6B
Target Involvement
Pachyonychia congenita 4 (PC4)
Target Protein Families
Intermediate filament family
Target Tissue Specificity
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.
Target Synonyms
CK-6B; CK6B; Cytokeratin-6B; K2C6B_HUMAN; K6b; Keratin; Keratin epidermal type II K6B; Keratin like 1 (a type II keratin sequence); Keratin type II cytoskeletal 6B; Keratin-6B; KRT6B; KRTL1; PC2; PC4; type II cytoskeletal 6B; Type-II keratin Kb10
Target Background
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
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