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The antibody against KYAT1 was raised in rabbit using the Recombinant Human Kynurenine--oxoglutarate transaminase 1 protein (1-372AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against KYAT1 was raised in rabbit using the Recombinant Human Kynurenine–oxoglutarate transaminase 1 protein (1-372AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human small intestine tissue using KYAT1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using KYAT1 Antibody at dilution of 1:1002
| Cat.No | ADC-45694A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KYAT1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kynurenine--oxoglutarate transaminase 1 protein (1-372AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q16773 |
Uniprot Id
Q16773
Target Species
Human
Target Name
KYAT1
Target Full Name
Kynurenine--oxoglutarate transaminase 1
Target Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
Class-I pyridoxal-phosphate-dependent aminotransferase family
Target Research Area
Metabolism
Target Synonyms
KYAT1; CCBL1; Kynurenine--oxoglutarate transaminase 1; EC 2.6.1.7; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; EC 2.6.1.64; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase I
Target Background
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.
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