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The antibody against KYNU was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human KYNU (NP_001028170.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against KYNU was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human KYNU (NP_001028170.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-02913A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KYNU |
| Target Synonyms | KYNUU; VCRL2; KYNU | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A549 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human KYNU (NP_001028170.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q16719 | Immunogen Sequence |
Uniprot Id
Q16719
Target Species
Human
Target Name
KYNU
Target Full Name
Kynureninase
Target Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Target Involvement
Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
Kynureninase family
Target Tissue Specificity
Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
Target Research Area
Signal Transduction
Target Synonyms
kynU; KYNU_HUMAN; kynureninase (L-kynurenine hydrolase); Kynureninase; L-kynurenine hydrolase
Target Background
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.
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