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The antibody against L3MBTL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against L3MBTL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01430A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | L3MBTL2 |
| Target Synonyms | L3MBT; H-l(3)mbt-l; L3MBTL2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HL-60, HT-29 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q969R5 | Immunogen Sequence |
Uniprot Id
Q969R5
Target Species
Human
Target Name
L3MBTL2
Target Full Name
Lethal(3)malignant brain tumor-like protein 2
Target Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Target Subcellular Location
Nucleus.
Target Synonyms
3bt like 2 protein; 3bt like protein; DKFZP761I141 ; H-l(3)mbt-like protein 2; H-l(3)mbt-like protein; Hl ; Hl(3)mbt like protein ; Hl(3)mbtl ; L; l(3)mbt like 2 (Drosophila) ; l(3)mbt like 2; L(3)mbt-like 2 protein; L(3)mbt-like protein 2; L3MBTL2; Lethal; Lethal(3)malignant brain tumor-like 2 protein; Lethal(3)malignant brain tumor-like protein 2; LMBL2_HUMAN
Target Background
Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus.
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