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The antibody against LARS was raised in rabbit using the Recombinant Human Leucine--tRNA ligase, cytoplasmic protein (614-892AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against LARS was raised in rabbit using the Recombinant Human Leucine–tRNA ligase, cytoplasmic protein (614-892AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Western Blot | Positive WB detected in: Hela whole cell lysate, Raji whole cell lysate, U251 whole cell lysate | All lanes: LARS antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 135, 129, 56 kDa | Observed band size: 135 kDa
| Cat.No | ADC-01783A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LARS |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine--tRNA ligase, cytoplasmic protein (614-892AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9P2J5 |
Uniprot Id
Q9P2J5
Target Species
Human
Target Name
LARS1
Target Full Name
Leucine--tRNA ligase, cytoplasmic
Target Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
Target Involvement
Infantile liver failure syndrome 1 (ILFS1)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class-I aminoacyl-tRNA synthetase family
Target Synonyms
cytoplasmic; Cytoplasmic leucyl tRNA synthetase; Cytosolic leucyl tRNA synthetase; FLJ10595; FLJ21788; hr025Cl; HSPC 192; HSPC192; KIAA1352; LARS 1; Lars; LARS1; Leucine translase; Leucine tRNA ligase; Leucine--tRNA ligase; Leucyl tRNA synthetase cytoplasmic; Leucyl-tRNA synthetase; LeuRS; LEUS; LRS; PIG 44; PIG44; Proliferation inducing gene 44; RNTLS; SYLC_HUMAN
Target Background
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.
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