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The antibody against LGALS3BP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 306-585 of human LGALS3BP (NP_005558.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against LGALS3BP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 306-585 of human LGALS3BP (NP_005558.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09406A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LGALS3BP |
| Target Synonyms | 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B; LGALS3BP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Rat brain, 293T, HepG2, HT-29, Mouse liver, Mouse lung, Rat lung | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 306-585 of human LGALS3BP (NP_005558.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q08380 | Immunogen Sequence |
Uniprot Id
Q08380
Target Species
Human
Target Name
LGALS3BP
Target Full Name
Galectin-3-binding protein
Target Function
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Target Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix.
Target Tissue Specificity
Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
Target Research Area
Cancer
Target Synonyms
(Basement membrane autoantigen p105)(Lectin galactoside-binding soluble 3-binding protein)(Mac-2-binding protein)(MAC2BP)(Mac-2 BP)(Tumor-associated antigen 90K)
Target Background
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
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