Rabbit anti-Human LGALS3BP Polyclonal Antibody

Uniprot Id

Q08380

Target Species

Human

Target Name

LGALS3BP

Target Full Name

Galectin-3-binding protein

Target Function

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

Target Subcellular Location

Secreted. Secreted, extracellular space, extracellular matrix.

Target Tissue Specificity

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.

Target Research Area

Cancer

Target Synonyms

(Basement membrane autoantigen p105)(Lectin galactoside-binding soluble 3-binding protein)(Mac-2-binding protein)(MAC2BP)(Mac-2 BP)(Tumor-associated antigen 90K)

Target Background

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.