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The antibody against LILRA4 was raised in rabbit using the Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 protein (289-424AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against LILRA4 was raised in rabbit using the Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 protein (289-424AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human skin tissue using LILRA4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using LILRA4 Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using LILRA4 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-24573A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LILRA4 |
| Target Synonyms | LILRA4; ILT7; Leukocyte immunoglobulin-like receptor subfamily A member 4; CD85 antigen-like family member G; Immunoglobulin-like transcript 7; ILT-7; CD antigen CD85g | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 protein (289-424AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P59901 |
Uniprot Id
P59901
Target Species
Human
Target Name
LILRA4
Target Full Name
Leukocyte immunoglobulin-like receptor subfamily A member 4
Target Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
Target Synonyms
LILRA4; ILT7; Leukocyte immunoglobulin-like receptor subfamily A member 4; CD85 antigen-like family member G; Immunoglobulin-like transcript 7; ILT-7; CD antigen CD85g
Target Background
This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4.
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