Rabbit anti-Human LOX Monoclonal Antibody

The antibody against LOX was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 318-417 of human LOX (P28300) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IP, ELISA.

ADA-16942A

Number

Cat.No	ADA-16942A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	LOX
Target Synonyms	AAT10; LOX	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, A549, Jurkat, Mouse lung, Rat lung, Rat spleen	Application	ELISA, WB, IHC-P, IP

Cat.No

ADA-16942A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

LOX

Target Synonyms

AAT10; LOX

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, A549, Jurkat, Mouse lung, Rat lung, Rat spleen

Application

ELISA, WB, IHC-P, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 318-417 of human LOX (P28300).	Target Species	Human
Immunogen Sequence	GHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY	Uniprot ID	P28300

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 318-417 of human LOX (P28300).

Target Species

Human

Immunogen Sequence

GHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Uniprot ID

P28300

Background Information

Uniprot Id

P28300
Target Species

Human
Target Name

LOX
Target Full Name

Protein-lysine 6-oxidase
Target Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
Target Involvement

Aortic aneurysm, familial thoracic 10 (AAT10)
Target Subcellular Location

Secreted. Secreted, extracellular space.
Target Protein Families

Lysyl oxidase family
Target Tissue Specificity

Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Target Research Area

Cardiovascular, Signal Transduction
Target Synonyms

lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase
Target Background

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.

Rabbit anti-Human LOX Monoclonal Antibody

Specifications

Immunogen Information

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