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The antibody against LOX was raised in rabbit using the Human LOX as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against LOX was raised in rabbit using the Human LOX as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-52854A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LOX |
| Target Synonyms | lox antibody; LYOX antibody; LYOX_HUMAN antibody; Lysyl oxidase antibody; MGC105112 antibody; Protein lysine 6 oxidase antibody; Protein-lysine 6-oxidase antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human LOX | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P28300 |
Uniprot Id
P28300
Target Species
Human
Target Name
LOX
Target Full Name
Protein-lysine 6-oxidase
Target Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
Target Involvement
Aortic aneurysm, familial thoracic 10 (AAT10)
Target Subcellular Location
Secreted. Secreted, extracellular space.
Target Protein Families
Lysyl oxidase family
Target Tissue Specificity
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Target Research Area
Cardiovascular, Signal Transduction
Target Synonyms
lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase
Target Background
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.
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