Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against LOXL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against LOXL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of mouse eye using LOXL1 Polyclonal Antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
| Cat.No | ADA-09003A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Loxl1 |
| Target Synonyms | LOL; LOXL; LOXL1 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Rat heart, A-549, A375, BT-474, HT-1080, Mouse lung | Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q08397 | Immunogen Sequence |
Uniprot Id
Q08397
Target Species
Human
Target Name
LOXL1
Target Full Name
Lysyl oxidase homolog 1
Target Function
Active on elastin and collagen substrates.
Target Involvement
Exfoliation syndrome (XFS)
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Lysyl oxidase family
Target Tissue Specificity
Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.
Target Research Area
Cell Biology, Metabolism
Target Synonyms
LOXL1; LOXLLysyl oxidase homolog 1; EC 1.4.3.-; Lysyl oxidase-like protein 1; LOL
Target Background
This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
