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The antibody against LRRFIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 589-809 of human LRRFIP1 (NP_001131024.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LRRFIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 589-809 of human LRRFIP1 (NP_001131024.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using LRRFIP1 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 45s.
| Cat.No | ADA-08188A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LRRFIP1 |
| Target Synonyms | GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1; LRRFIP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Daudi, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 589-809 of human LRRFIP1 (NP_001131024.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q32MZ4 | Immunogen Sequence |
Uniprot Id
Q32MZ4
Target Species
Human
Target Name
LRRFIP1
Target Full Name
Leucine-rich repeat flightless-interacting protein 1
Target Function
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
LRRFIP family
Target Tissue Specificity
Ubiquitously expressed.
Target Research Area
Transcription
Target Synonyms
FLAP 1; FLAP1; FLIIAP 1; FLIIAP1; GC binding factor 2; GC-binding factor 2; GCF 2; GCF2; HUFI 1; HUFI1; Leucine rich repeat (in FLII) interacting protein 1; Leucine rich repeat flightless interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII interacting protein 1; LRR FLII-interacting protein 1; LRRF1_HUMAN; LRRFIP 1; Lrrfip1; MGC10947; MGC119738; MGC119739; NEDD8 conjugating enzyme; TAR RNA interacting protein; TAR RNA-interacting protein; Transcription factor 9 like; TRIP
Target Background
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane.
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