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The antibody against LRRFIP2 was raised in rabbit using the Recombinant Human Leucine-rich repeat flightless-interacting protein 2 protein (211-342AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against LRRFIP2 was raised in rabbit using the Recombinant Human Leucine-rich repeat flightless-interacting protein 2 protein (211-342AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-07227A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LRRFIP2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine-rich repeat flightless-interacting protein 2 protein (211-342AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y608 |
Uniprot Id
Q9Y608
Target Species
Human
Target Name
LRRFIP2
Target Full Name
Leucine-rich repeat flightless-interacting protein 2
Target Function
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Target Protein Families
LRRFIP family
Target Tissue Specificity
Widely expressed, with highest levels in heart and skeletal muscle.
Target Synonyms
5133400F20Rik; AI850587; DKFZp434H2035; FLJ20248; FLJ22683; FLJ58304; HUFI 2; Leucine rich repeat (in FLII) interacting protein 2; Leucine rich repeat flightless interacting protein 2; Leucine-rich repeat flightless-interacting protein 2; LRR FLII interacting protein 2; LRR FLII-interacting protein 2; LRRF2_HUMAN; Lrrfip2
Target Background
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.
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