Rabbit anti-Human LRSAM1 Polyclonal Antibody

Uniprot Id

Q6UWE0

Target Species

Human

Target Name

LRSAM1

Target Full Name

E3 ubiquitin-protein ligase LRSAM1

Target Function

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).

Target Involvement

Charcot-Marie-Tooth disease 2P (CMT2P)

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.

Target Synonyms

CMT2P; E3 ubiquitin protein ligase LRSAM1; E3 ubiquitin-protein ligase LRSAM1; EC 6.3.2.-; FLJ31641 ; hTAL; Leucine rich repeat and sterile alpha motif containing 1; Leucine rich repeat and sterile alpha motif containing protein 1; Leucine-rich repeat and sterile alpha motif-containing protein 1; LRSAM1; LRSM1_HUMAN; OTTHUMP00000022174 ; OTTHUMP00000022175 ; RIFLE ; TAL ; Tsg101 associated ligase; Tsg101-associated ligase

Target Background

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.