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The antibody against LTBP4 was raised in rabbit using the Recombinant Human Latent-transforming growth factor beta-binding protein 4 protein (977-1180AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against LTBP4 was raised in rabbit using the Recombinant Human Latent-transforming growth factor beta-binding protein 4 protein (977-1180AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using LTBP4 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using LTBP4 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-15732A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LTBP4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Latent-transforming growth factor beta-binding protein 4 protein (977-1180AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N2S1 |
Uniprot Id
Q8N2S1
Target Species
Human
Target Name
LTBP4
Target Full Name
Latent-transforming growth factor beta-binding protein 4
Target Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Target Involvement
Urban-Rifkin-Davis syndrome (URDS); Duchenne muscular dystrophy (DMD)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
LTBP family
Target Tissue Specificity
Highly expressed in heart, skeletal muscle, pancreas, uterus, and small intestine. Weakly expressed in placenta and lung.
Target Synonyms
latent transforming growth factor beta binding protein 4; latent transforming growth factor beta binding protein 4L; Latent-transforming growth factor beta-binding protein 4; LTBP 4; LTBP-4; LTBP4; LTBP4_HUMAN; LTBP4L; LTBP4S
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