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The antibody against LZTR1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LZTR1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of lysates from C6 cells, using LZTR1 Rabbit pAb at 1:2000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
| Cat.No | ADA-02561A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LZTR1 |
| Target Synonyms | NS2; NS10; BTBD29; LZTR-1; SWNTS2; LZTR1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | C6 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N653 | Immunogen Sequence |
Uniprot Id
Q8N653
Target Species
Human
Target Name
LZTR1
Target Full Name
Leucine-zipper-like transcriptional regulator 1
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
Target Involvement
Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)
Target Subcellular Location
Endomembrane system. Recycling endosome. Golgi apparatus.
Target Synonyms
Leucine zipper like regulator 1; Leucine zipper like transcription regulator 1; Leucine-zipper-like transcriptional regulator 1; LZTR-1; Lztr1; LZTR1_HUMAN; MGC21205; TCFL2
Target Background
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome.
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