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The antibody against LZTR1 was raised in rabbit using the Recombinant Human Leucine-zipper-like transcriptional regulator 1 protein (300-545AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against LZTR1 was raised in rabbit using the Recombinant Human Leucine-zipper-like transcriptional regulator 1 protein (300-545AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human heart tissue using LZTR1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using LZTR1 Antibody at dilution of 1:1002
| Cat.No | ADC-17136A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LZTR1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine-zipper-like transcriptional regulator 1 protein (300-545AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N653 |
Uniprot Id
Q8N653
Target Species
Human
Target Name
LZTR1
Target Full Name
Leucine-zipper-like transcriptional regulator 1
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
Target Involvement
Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)
Target Subcellular Location
Endomembrane system. Recycling endosome. Golgi apparatus.
Target Synonyms
Leucine zipper like regulator 1; Leucine zipper like transcription regulator 1; Leucine-zipper-like transcriptional regulator 1; LZTR-1; Lztr1; LZTR1_HUMAN; MGC21205; TCFL2
Target Background
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome.
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