Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against MACF1 was raised in rabbit using the Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against MACF1 was raised in rabbit using the Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-01757A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MACF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPN3 |
Uniprot Id
Q9UPN3
Target Species
Human
Target Name
MACF1
Target Full Name
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5
Target Function
F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells. As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development.
Target Subcellular Location
[Isoform 2]: Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane.; [Isoform 1]: Cytoplasm. Golgi apparatus.
Target Protein Families
Plakin or cytolinker family
Target Tissue Specificity
Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.
Target Synonyms
MACF1; ABP620; ACF7; KIAA0465; KIAA1251; Microtubule-actin cross-linking factor 1; isoforms 1/2/3/5; 620 kDa actin-binding protein; ABP620; Actin cross-linking family protein 7; Macrophin-1; Trabeculin-alpha
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
