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The antibody against MAGEA4 was raised in rabbit using the Recombinant Human Melanoma-associated antigen 4 protein (1-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MAGEA4 was raised in rabbit using the Recombinant Human Melanoma-associated antigen 4 protein (1-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using MAGEA4 Antibody at dilution of 1:100
| Cat.No | ADC-24495A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAGEA4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Melanoma-associated antigen 4 protein (1-270AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P43358 |
Uniprot Id
P43358
Target Species
Human
Target Name
MAGEA4
Target Full Name
Melanoma-associated antigen 4
Target Function
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
Target Tissue Specificity
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
Target Research Area
Cancer
Target Synonyms
Cancer/testis antigen 1.4; CT1.4; MAGA4_HUMAN; MAGE 4; MAGE 4 antigen; MAGE 41; MAGE 41 antigen; MAGE 4A; MAGE 4B; MAGE X2; MAGE X2 antigen; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen; MAGE4; MAGE41; MAGE4A; MAGE4B; MAGEA 4; MAGEA4; Melanoma antigen family A 4; Melanoma associated antigen 4; Melanoma-associated antigen 4; MGC21336
Target Background
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene.
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