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The antibody against MAGEL2 was raised in rabbit using the Synthetic peptide of Human MAGEL2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against MAGEL2 was raised in rabbit using the Synthetic peptide of Human MAGEL2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26399A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAGEL2 |
| Target Synonyms | MAGEL2 antibody; NDNL1 antibody; MAGE-like protein 2 antibody; Necdin-like protein 1 antibody; Protein nM15 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human MAGEL2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UJ55 |
Uniprot Id
Q9UJ55
Target Species
Human
Target Name
MAGEL2
Target Full Name
MAGE-like protein 2
Target Function
Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK.
Target Involvement
Schaaf-Yang syndrome (SHFYNG)
Target Subcellular Location
Early endosome. Cytoplasm. Nucleus.
Target Tissue Specificity
Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient.
Target Synonyms
MAGEL2; NDNL1; MAGE-like protein 2; Necdin-like protein 1; Protein nM15
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