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The antibody against MAN1B1 was raised in rabbit using the Synthesized peptide derived from internal of Human MAN1B1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against MAN1B1 was raised in rabbit using the Synthesized peptide derived from internal of Human MAN1B1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from 3T3 cells, using MAN1B1 antibody.
| Cat.No | ADC-41245A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAN1B1 |
| Target Synonyms | 2-alpha-mannosidase antibody; EC 3.2.1.113 antibody; ER alpha-1, 2-mannosidase antibody; ER mannosidase 1 antibody; ERMan1 antibody; Man9GlcNAc2-specific-processing alpha-mannosidase antibody; Mannosidase alpha class 1B member 1 antibody, MAN1B1 antibody; UNQ747/PRO1477Endoplasmic reticulum mannosyl-oligosaccharide 1 | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human MAN1B1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UKM7 |
Uniprot Id
Q9UKM7
Target Species
Human
Target Name
MAN1B1
Target Full Name
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Target Function
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).
Target Involvement
Mental retardation, autosomal recessive 15 (MRT15)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyl hydrolase 47 family
Target Tissue Specificity
Widely expressed.
Target Synonyms
MAN1B1; UNQ747/PRO1477Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; EC 3.2.1.113; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1
Target Background
This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1, 2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.
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