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The antibody against MAN2A1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 865-1144 of human MAN2A1 (NP_002363.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MAN2A1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 865-1144 of human MAN2A1 (NP_002363.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06463A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAN2A1 |
| Target Synonyms | MANA2; MANII; GOLIM7; AMan II; MAN2A1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-1080, HT-29, LO2, MCF7, Mouse liver, NCI-H460, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 865-1144 of human MAN2A1 (NP_002363.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q16706 | Immunogen Sequence |
Uniprot Id
Q16706
Target Species
Human
Target Name
MAN2A1
Target Full Name
Alpha-mannosidase 2
Target Function
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyl hydrolase 38 family
Target Synonyms
3-1; 6-alpha-mannosidase; Alpha mannosidase 2; alpha Mannosidase II; Alpha-mannosidase 2; AMAN II; Golgi alpha mannosidase II; Golgi alpha-mannosidase II; Golgi integral membrane protein 7; GOLIM7; MA2A1_HUMAN; MAN II; Man2a1; MANA 2; MANA2; MANII; Mann II; Mannosidase alpha class 2A member 1; Mannosidase Two; Mannosidase; alpha type II; Mannosidase; alpha; II; Mannosyl oligosaccharide 1 3 1 6 alpha mannosidase; Mannosyl oligosaccharide 1,3 1,6 alpha mannosidase; Mannosyl-oligosaccharide 1
Target Background
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
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