Rabbit anti-Human MARK1 Polyclonal Antibody

The antibody against MARK1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 560-700 of human MARK1 (NP_061120.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09016A

Number

Cat.No	ADA-09016A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MARK1
Target Synonyms	MARK; Par1c; Par-1c; MARK1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, U-87MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-09016A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MARK1

Target Synonyms

MARK; Par1c; Par-1c; MARK1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, U-87MG

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 560-700 of human MARK1 (NP_061120.3).	Target Species	Human
Immunogen Sequence	HPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSL	Uniprot ID	Q9P0L2

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 560-700 of human MARK1 (NP_061120.3).

Target Species

Human

Immunogen Sequence

HPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSL

Uniprot ID

Q9P0L2

Background Information

Uniprot Id

Q9P0L2
Target Species

Human
Target Name

MARK1
Target Full Name

Serine/threonine-protein kinase MARK1
Target Function

Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Target Involvement

Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
Target Subcellular Location

Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, dendrite.
Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Target Tissue Specificity

Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Target Synonyms

KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK 1; MARK; Mark1; MARK1_HUMAN; MGC126512; MGC126513; Serine/threonine protein kinase MARK1; Serine/threonine-protein kinase MARK1
Target Background

Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane.

Rabbit anti-Human MARK1 Polyclonal Antibody

Specifications

Immunogen Information

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