Rabbit anti-Human MATK Polyclonal Antibody

Uniprot Id

P42679

Target Species

Human

Target Name

MATK

Target Full Name

Megakaryocyte-associated tyrosine-protein kinase

Target Function

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Target Subcellular Location

Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Target Protein Families

Protein kinase superfamily, Tyr protein kinase family, CSK subfamily

Target Tissue Specificity

Expressed in various myeloid cell lines, detected in brain and lung.

Target Synonyms

CHK ; Csk homologous kinase; Csk type protein tyrosine kinase; CTK ; DKFZp434N1212 ; EC 2.7.10.2; Hematopoietic consensus tyrosine lacking kinase; Hematopoietic consensus tyrosine-lacking kinase; HHYLTK ; Hydroxyaryl protein kinase ; HYL ; HYL tyrosine kinase; HYLTK ; Leukocyte carboxyl terminal src kinase related; Lsk ; matK; MATK_HUMAN; Megakaryocyte associated tyrosine kinase; Megakaryocyte associated tyrosine protein kinase; Megakaryocyte-associated tyrosine-protein kinase; MGC1708 ; MGC2101 ; Protein kinase HYL; Tyrosine kinase MATK; Tyrosine protein kinase CTK; Tyrosine-protein kinase CTK; Tyrosylprotein kinase

Target Background

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.