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The antibody against MBTPS2 was raised in rabbit using the Synthesized peptide derived from internal of Human MBTPS2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IF.
The antibody against MBTPS2 was raised in rabbit using the Synthesized peptide derived from internal of Human MBTPS2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IF.
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Immunofluorescence analysis of A549 cells, using MBTPS2 antibody.
| Cat.No | ADC-41145A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MBTPS2 |
| Target Synonyms | site 2 antibody; membrane-bound transcription factor protease | Form | Liquid |
| Species Reactivity | Human, Mouse | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human MBTPS2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43462 |
Uniprot Id
O43462
Target Species
Human
Target Name
MBTPS2
Target Full Name
Membrane-bound transcription factor site-2 protease
Target Function
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation.
Target Involvement
IFAP syndrome with or without BRESHECK syndrome (IFAPS); Olmsted syndrome, X-linked (OLMSX); Keratosis follicularis spinulosa decalvans X-linked (KFSDX)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cytoplasm.
Target Protein Families
Peptidase M50A family
Target Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Target Synonyms
BRESEK; Endopeptidase S2P; IFAP; KFSDX; MBTP2_HUMAN; MBTPS2; Membrane bound transcription factor site 2 protease; membrane-bound transcription factor peptidase, site 2; membrane-bound transcription factor protease, site 2; Membrane-bound transcription factor site-2 protease; S2P; S2P endopeptidase; Site 2 protease; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease
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