Rabbit anti-Human MCF2 Polyclonal Antibody

The antibody against MCF2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 872-1001 of human MCF2 (NP_001165347.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03275A

Number

Cat.No	ADA-03275A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MCF2
Target Synonyms	DBL; ARHGEF21; MCF2	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HT-29	Application	ELISA, WB

Cat.No

ADA-03275A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MCF2

Target Synonyms

DBL; ARHGEF21; MCF2

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HT-29

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 872-1001 of human MCF2 (NP_001165347.1).	Target Species	Human
Immunogen Sequence	VKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY	Uniprot ID	P10911

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 872-1001 of human MCF2 (NP_001165347.1).

Target Species

Human

Immunogen Sequence

VKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY

Uniprot ID

P10911

Background Information

Uniprot Id

P10911
Target Species

Human
Target Name

MCF2
Target Full Name

Proto-oncogene DBL
Target Function

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Target Involvement

MCF2 and DBL represent two activated versions of the same proto-oncogene.
Target Subcellular Location

Cytoplasm.; [Isoform 1]: Membrane.; [Isoform 3]: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
Target Protein Families

MCF2 family
Target Tissue Specificity

Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, int
Target Synonyms

MCF2; DBLProto-oncogene DBL; Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein]
Target Background

The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.

Rabbit anti-Human MCF2 Polyclonal Antibody

Specifications

Immunogen Information

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