Rabbit anti-Human MCF2 Polyclonal Antibody, FITC conjugated

Uniprot Id

P10911

Target Species

Human

Target Name

MCF2

Target Full Name

Proto-oncogene DBL

Target Function

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

Target Involvement

MCF2 and DBL represent two activated versions of the same proto-oncogene.

Target Subcellular Location

Cytoplasm.; [Isoform 1]: Membrane.; [Isoform 3]: Membrane. Note=Colocalizes with CDC42 to plasma membrane.

Target Protein Families

MCF2 family

Target Tissue Specificity

Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, int

Target Synonyms

MCF2; DBLProto-oncogene DBL; Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein]

Target Background

The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.