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The antibody against MCM9 was raised in rabbit using the Recombinant Human DNA helicase MCM9 protein (1-391AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IF.
The antibody against MCM9 was raised in rabbit using the Recombinant Human DNA helicase MCM9 protein (1-391AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IF.
$299.00
Western Blot Positive WB detected in: 293 whole cell lysate, MCF7 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate, Mouse Brain tissue lysate, Mouse Brain tissue lysate All lanes: MCM9 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 127/85/72/48 kDa Observed band size: 127 kDa
Immunofluorescence staining of MCF7 cell with MCM9 Antibody at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).2
Immunofluorescence staining of MCF7 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).3
| Cat.No | ADC-24463A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MCM9 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.02% sodium azide; Constituents: PBS containing 50% glycerol |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA helicase MCM9 protein (1-391AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NXL9 |
Uniprot Id
Q9NXL9
Target Species
Human
Target Name
MCM9
Target Full Name
DNA helicase MCM9
Target Function
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
Target Involvement
Ovarian dysgenesis 4 (ODG4)
Target Subcellular Location
Nucleus. Chromosome.
Target Protein Families
MCM family
Target Research Area
Cell Biology
Target Synonyms
MCM9; C6orf61; MCMDC1DNA helicase MCM9; hMCM9; EC 3.6.4.12; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9
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