Rabbit anti-Human MCMBP Polyclonal Antibody

The antibody against MCMBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04209A

Number

Cat.No	ADA-04209A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MCMBP
Target Synonyms	MCM-BP; C10orf119; MCMBP	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-431, Mouse liver, Mouse ovary, Mouse spleen	Application	ELISA, WB

Cat.No

ADA-04209A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MCMBP

Target Synonyms

MCM-BP; C10orf119; MCMBP

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-431, Mouse liver, Mouse ovary, Mouse spleen

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1).	Target Species	Human
Uniprot ID	Q9BTE3	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1).

Target Species

Human

Uniprot ID

Q9BTE3

Immunogen Sequence

Background Information

Uniprot Id

Q9BTE3
Target Species

Human
Target Name

MCMBP
Target Full Name

Mini-chromosome maintenance complex-binding protein
Target Function

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
Target Subcellular Location

Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
Target Protein Families

MCMBP family
Target Synonyms

MCMBP; C10orf119; Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein
Target Background

This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human MCMBP Polyclonal Antibody

Specifications

Immunogen Information

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