Rabbit anti-Human MCT1/SLC16A1 Polyclonal Antibody

Uniprot Id

P53985

Target Species

Human

Target Name

SLC16A1

Target Full Name

Monocarboxylate transporter 1

Target Function

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Target Involvement

Symptomatic deficiency in lactate transport (SDLT); Familial hyperinsulinemic hypoglycemia 7 (HHF7); Monocarboxylate transporter 1 deficiency (MCT1D)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family

Target Tissue Specificity

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.

Target Synonyms

FLJ36745; HHF7; MCT 1; MCT; MGC44475; Monocarboxylate transporter 1; Monocarboxylate transporter; Monocarboxylate transporter isoform 1; Monocarboxylic acid transporter 1; MOT1_HUMAN; Slc16a1; SLC16A1 protein; Solute carrier family 16 (monocarboxylic acid transporters) member 1; Solute carrier family 16 member 1 (monocarboxylic acid transporter 1); Solute carrier family 16 member 1

Target Background

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.